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KMID : 0043320050280080936
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Archives of Pharmacal Research
2005 Volume.28 No. 8 p.936 ~ p.941
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In Vitro Stimulation of Murine Peritoneal Monocytes Induced by Alginates
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Paolo Pasquali
Amy Zalcman
Susanna Murtas
Rosanna Adone
Gianfranco Brambilla
Cinzia Marianelli
Monica Cagiol
Franco Ciuchini
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Abstract
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In this trial we assessed the effect of soluble alginates on murine cells. Mouse peritoneal monocytes were stimulatedin vitro with a solution of alginate. The production of TNF-α and nitric oxide (NO), the expression of surface molecules CD80 and CD86, and the ability of monocytes to phagocyte bacteria were assessed, in order to evaluate the effect of alginate on cell functionality. We showed that mouse peritoneal monocytes stimulated with alginate produce NO and TNF-α. In addition, alginate is able also to increase their phagocytic activity and to a lesser extent also to increase the expression of CD80. Even with different degrees, it implies that alginatesper se act directly on immune response, being able to effectively stimulate proinflammatory activity. These findings corroborate the idea that alginates can represent interesting adjuvants to use to increase the efficacy of antigenic stimulation.
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